What is fosfomycin calcium
Fosfomycin calcium is a broad-spectrum antibiotic that belongs to the calcium salt form of fosfomycin drugs. It exerts antibacterial effects by inhibiting the synthesis of bacterial cell walls and has good effects on a variety of Gram-positive and Gram-negative bacteria. In recent years, the clinical application of fosfomycin calcium has gradually increased, especially in the treatment of urinary tract infections, respiratory infections, and skin and soft tissue infections.
Here is some basic information about fosfomycin calcium:
| property | content |
|---|---|
| chemical name | fosfomycin calcium |
| English name | Fosfomycin Calcium |
| Molecular formula | C3H5CaO4P |
| Indications | Urinary tract infection, respiratory tract infection, skin and soft tissue infection, etc. |
| Mechanism of action | Inhibit bacterial cell wall synthesis |
| Common dosage forms | Tablets, granules |
Pharmacological effects of fosfomycin calcium
Fosfomycin calcium exerts a bactericidal effect by inhibiting the early synthesis stage of the bacterial cell wall and blocking the production of peptidoglycan. It also shows good activity against a variety of drug-resistant strains, so it is regarded as an important alternative antibiotic in clinical practice.
The following is the antibacterial spectrum of fosfomycin calcium against common pathogenic bacteria:
| Bacteria type | sensitivity |
|---|---|
| Escherichia coli | highly sensitive |
| Staphylococcus aureus | sensitive |
| Klebsiella pneumoniae | sensitive |
| Pseudomonas aeruginosa | Partially sensitive |
| Enterococci | Moderately sensitive |
Clinical application of fosfomycin calcium
Fosfomycin calcium is mainly used clinically to treat the following infections:
1.urinary tract infection: Fosfomycin calcium has a high concentration in urine and has a significant effect on common urinary tract pathogens such as Escherichia coli.
2.respiratory tract infection: Including pneumonia, bronchitis, etc., especially patients who are resistant to penicillin antibiotics.
3.Skin and soft tissue infections: Such as boils, carbuncles, cellulitis, etc.
The following is the recommended dosage of fosfomycin calcium:
| Indications | Adult dosage | Pediatric dosage |
|---|---|---|
| urinary tract infection | 3g each time, once a day | Calculated based on body weight, 50-100mg/kg per day |
| respiratory tract infection | 3g each time, 2 times a day | Calculated based on body weight, 100-150mg/kg per day |
| skin infection | 3g each time, 1-2 times a day | Calculated based on body weight, 50-100mg/kg per day |
Adverse reactions and precautions of fosfomycin calcium
Fosfomycin calcium has relatively few adverse reactions, common ones include:
1.gastrointestinal reactions: Such as nausea, vomiting, diarrhea, etc.
2.allergic reaction: A few patients may develop rash, itching, etc.
3.abnormal liver function: Long-term and large-dose use may cause elevated transaminases.
Please note the following when using fosfomycin calcium:
1. It is prohibited for those who are allergic to fosfomycin.
2. Patients with renal insufficiency need to adjust the dosage.
3. Use with caution by pregnant and lactating women.
4. It should not be taken together with metal ion preparations to avoid affecting absorption.
Fosfomycin calcium market status
In recent years, as the problem of antibiotic resistance has become increasingly serious, the market demand for fosfomycin calcium has gradually increased. According to the latest statistics, the sales of fosfomycin calcium in the domestic market have shown a steady upward trend.
The following is the market data of fosfomycin calcium in the past three years:
| years | Sales (billion yuan) | growth rate |
|---|---|---|
| 2021 | 5.2 | 12% |
| 2022 | 6.0 | 15% |
| 2023 | 7.1 | 18% |
Summarize
As a broad-spectrum antibiotic, fosfomycin calcium has unique advantages in treating a variety of bacterial infections. Its unique antibacterial mechanism and good safety make it an important choice in clinical practice. With the increase in drug-resistant strains, the application prospects of fosfomycin calcium will be broader. However, rational use of antibiotics and avoidance of abuse are still issues that clinicians and patients need to pay attention to.
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